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Single-cell Epigenetics
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Epigenetic alterations caused by interaction between transcription factors and chromatin regulators control cell state transitions by activating or suppressing specific set of genes. We defined the cell states in rhabdomyosarcoma, and other solid tumors, with the cell state transition dynamics unsolved. We propose that a perturbation of gene regulatory elements, or specific TFs or chromatin regulators could direct cells towards a specific cell state.
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Publications:
Danielli SG*, Wei Y*, Dyer MA, Stewart E, Wachtel M, Schäfer BW, Patel AG, Langenau DM. “Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma”. Nature Communications, 2024
Wei Y*, Qin Q*, Yan C, Hayes MN, Garcia SP, Xi H, Do D, Jin AH, Eng TC, McCarthy KM, Adhikari A, Onozato ML, Spentzos D, Nielsen GP, Iafrate AJ, Wexler LH, Pyle AD, Suvà ML, Cruz FD, Pinello L, Langenau DM. “Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma”, Nature Cancer, 2022.