We are hiring! Contact Yun.Wei@UTSouthwestern.edu for more details.
Modeling of rare tumors
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In contingent to 2nd research topic, any other type of oncogenes could be introduced simultaneously. We will employ transgenic zebrafish, or mouse models, or in vitro stem cell culture to model such rare tumors for detailed mechanism studies. Then patient-derived samples, either frozen or FFPE, or primary cell culture, patient-derived xenograft, or even organoids to validate our bench findings. This ensures the translational value of our hard work on bench.
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Publications:
Wei Y*, Corchete Sanchez LA*, Mathavarajah S, Antelo D, Wang S, Weissman AD, Qin Q, Lee J, Danielli SG, Eng TC, Veloso A, Wang Y, Neilsen GP, Patel AG, Rivera MN, Rheinbay E, Langenau DM. “Rewiring of cancer stem cell pathways by a DNA binding mutation in the MYOD1 myogenic transcription factor”. Submitted.
Danielli SG*, Wei Y*, Dyer MA, Stewart E, Wachtel M, Schäfer BW, Patel AG, Langenau DM. “Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma”. Nature Communications, 2024
Wei Y*, Qin Q*, Yan C, Hayes MN, Garcia SP, Xi H, Do D, Jin AH, Eng T, McCarthy KM, Adhikari A, Onozato ML, Spentzos D, Nielsen GP, Iafrate AJ, Wexler LH, Pyle AD, Suvà ML, Cruz FD, Pinello L, Langenau DM. “Single-cell analysis and functional characterization uncover the stem cell hierarchies and developmental origins of rhabdomyosarcoma”, Nature Cancer, 2022.
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