Fusion oncogenes in pediatric solid tumors

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A handful of fusion oncogenes were well studied in leukemia, Ewing sarcoma, and rhabdomyosarcomas. Yet, thousands of fusion genes have been discovered across pediatric solid tumors, though less frequent but always associated with worse prognosis in patients. Family members who have kids died of rare tumors that bear these fusions are desperate to know more. Yet, such type of research is rarely funded. We hope to first generate list of putative fusions, then model these fusion genes in lab models, and finally understand the mechanism of it by comprehensive profiling. 

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